Definition
The histopathological grade or differentiation describes how much the tumour resembles the normal tissue from which it arose, as represented by a code.
For lymphohaematopoietic neoplasms (leukaemias and lymphomas) this data element is used to denote cell lineage.
Components
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Data Element ConceptPerson with cancer—histopathological grade
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Object ClassPerson with cancer
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PropertyHistopathological grade
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Value DomainHistopathological grade code N
Representation
This representation is based on the value domain for this data element, more information is available at " Histopathological grade code N ".| Data Type | Number |
|---|---|
| Format | N |
| Maximum character length | 1 |
| Value | Meaning | Start Date | End Date | |
|---|---|---|---|---|
| Permissible Values | 1 | Grade 1: Low grade; well differentiated, differentiated, NOS | ||
| 2 | Grade 2: Intermediate grade, moderately differentiated, moderately well differentiated, intermediate differentiation | |||
| 3 | Grade 3: High grade, poorly differentiated | |||
| 4 | Grade 4: Undifferentiated, anaplastic | |||
| 5 | T-cell: T-cell | |||
| 6 | B-cell: B-cell, Pre-B, B-Precursor | |||
| 7 | Null-cell: Null cell, Non T- non B | |||
| 8 | NK-cell: Natural killer cell | |||
| Supplementary Values | 9 | Grade/differentiation unknown: Grade/cell type not determined, not stated or not applicable |
Comments
Guide for use:
Only one code can be recorded.
When more than one grade is documented for the primary tumour within the same specimen report, use the highest grade. For example, if grade 2-3 is documented, record the grade as 3.
If the grades differ on multiple pathology reports for the same tumour, use the value from the larger specimen (for example, the grade from a surgical excision specimen would be used over the grade from a specimen from a diagnostic biopsy).
Breast cancer coding rules:
Use the Nottingham grade (Elston-Ellis modification of Bloom-Richardson grading system). This classification only uses grades 1-3, 9.
For an invasive tumour with an in situ component, record the grade for the invasive component only. If the grade of the invasive component is not reported, record the grade as unknown.
Origin:
World Health Organisation
Commission on Cancer American College of Surgeons
References
World Health Organisation International Classification of Diseases Oncology, Third edition (ICD-O-3) (2000)
Commission on Cancer, Standards of the Commission on Cancer Registry Operations and Data Standards (ROADS) Volume II (1998)
Johnson CH, Adamo M (eds.), SEER Program Coding and Staging Manual 2007. National Cancer Institute, NIH Publication number 07-5581, Bethesda, MD 2007.
This content Based on Australian Institute of Health and Welfare material. Attribution provided as required under the AIHW CC-BY licence.